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Advise sufferers that: Tramadol Hydrochloride Prolonged-Release is for oral use only and may be swallowed full. The capsule shouldn't be chewed, dissolved, crushed or split. Tramadol Hydrochloride Prolonged-Launch may well lead to seizures and/or serotonin syndrome with concomitant use of serotonergic brokers (together with SRIs, NRIs, and triptans